This talk will introduce the biology of the most abundant forms of stem/progenitor cell in the adult CNS - the OPC , its involvement in regeneration and adaptive learning, and its central role in why both these functions decline with aging. Published and unpublished data will be presented on how the age-state of the OPC is determined in very large part by extrinsic factors, primarily the mechanical features of the niche, and how the reprograming factor myc acts as a key regulator of age state.
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