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Rahul Roychoudhuri discusses research linking genetic variation with susceptibility to inflammatory disease with the Cambridge Independent

Work by Rahul Roychoudhuri, in collaboration with the Wellcome Sanger Institute, has shed light on how a key genetic switch helps immune responses remain in check. As reported by Paul Brackley in the , the ‘dark matter’ switch may be an important key to understanding inflammatory diseases.

Rahul said: “Studies such as these will enable us to link the genetic switches that commonly reside in such disease-associated non-coding regions with the genes they control in different cell types. This will yield new insights into the cell types and genes underlying disease biology and provide new targets for therapeutic development.”

For more on the research, published in Nature, see our write-up: Uncovering how ‘dark matter’ regions of the genome affect inflammatory disease.